A2M (Alpha-2-Macroglobulin) is a naturally occurring molecule found in your blood. It acts as a powerful protector against cartilage breakdown by inhibiting proteins that damage joints and cause inflammation.. Similar to a Venus flytrap, A2M captures these destructive elements with its two binding sites and eliminates them through the body’s natural processes.

While A2M is the body’s own defense mechanism, its complex structure prevents it from entering the joint or disc space in large enough quantities. As a result, additional concentrated A2M must be injected into the affected area to restore balance and possibly relieve pain.

Through a patented and proprietary process, Alpha2Active or A2M isolates and concentrates A2M from your blood for reinjection at the injury site. This concentration boosts natural healing and supports tissue restoration.

A simple test performed by our staff can help determine if you’re a good candidate for Alpha2Active-A2M therapy. Research has identified the “pain protein” FAC (Fibronectin-Aggrecan Complex), which is associated with painful inflammation. The diagnostic test, called FACT (Fibronectin-Aggrecan Complex Test), looks for this unique biomarker in your joint or disc space to identify the presence of destructive enzymes that Alpha2Active-A2M can remove.

Early treatment typically leads to better recovery. Learn more about Alpha2Active-A2M and how it can benefit your joint health.

Specialized restorative therapies that enhance your body’s natural healing capabilities. Our experts bring industry-leading knowledge in orthobiologic therapies and interventional spine procedures to accelerate your recovery and help you return to your everyday life.

Regenerative orthobiologics use substances from your own body to aid the healing process, leveraging their restorative qualities. These therapies tap into the body’s innate capabilities to respond to physical conditions, working to replace, repair, or promote tissue health. As a result, they offer pain relief and improved mobility for orthopedic patients. Our procedures are backed by decades of evidence-based research and advancements.